Toxicology and Adverse Drug Reactions
نویسنده
چکیده
Toxicology has two main goals in relation to adverse drug reactions (ADRs). The first is to identify and characterize the potential for harmful effects that can be produced in biological systems, particularly laboratory animals, by a drug, and to suggest therapeutic circumstances in which toxic responses may occur and/or are unlikely to occur. The second is necessary when unexpected adverse clinical reactions are detected, i.e. those not predicted by conventional animal and clinical studies, and to investigate the mechanism in additional toxicological studies, often of nonstandard design, in order to understand these reactions and possibly how to avoid or ameliorate them.
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